What is the most common gestational trophoblastic neoplasia form following a pregnancy?

• A. Choriocarcinoma
• B. Placental site trophoblastic tumor
• C. Epithelioid trophoblastic tumor
• D. Invasive mole

Answer: (A)

Choriocarcinoma is the form most often seen after a pregnancy among gestational trophoblastic neoplasias. This malignant tumor arises from trophoblastic tissue and can develop after any pregnancy—molar, normal, or after abortion—making it the most common GTN encountered in this setting. It typically produces very high levels of human chorionic gonadotropin (hCG), which helps in both diagnosis and monitoring. Because it tends to spread hematogenously early, especially to the lungs, prompt recognition and chemotherapy are crucial, and outcomes are often good with appropriate treatment. Invasive mole, placental site trophoblastic tumor, and epithelioid trophoblastic tumor are far less common, which is why choriocarcinoma stands out as the most frequent GTN after pregnancy.