Malignant fibrous histiocytoma is most commonly a sarcoma found in which tissue?

• A. Soft tissue sarcoma of muscle and tendons
• B. Bone
• C. Lymph nodes
• D. Skin

Answer: (A)

Malignant fibrous histiocytoma is a soft-tissue sarcoma. It arises from the connective tissues of the soft tissues, most often in the extremities or retroperitoneum, rather than from bone, skin, or lymph nodes. That’s why the best description is a soft tissue sarcoma of muscle and tendons. (In modern pathology many MFH cases are now reclassified as undifferentiated pleomorphic sarcoma, but the concept remains that it originates in soft tissue, not bone or skin.)