CA 19-9 is a tumor marker most associated with which cancer?

Prepare for the NBME Form 10 Step 2 Test. Utilize flashcards and multiple choice questions, with hints and explanations for each. Ace your exam preparation!

Multiple Choice

CA 19-9 is a tumor marker most associated with which cancer?

Explanation:
CA 19-9 is a tumor marker most closely linked to pancreatic cancer. It is a carbohydrate antigen produced by pancreatic ductal cells, and levels tend to be elevated in pancreatic adenocarcinoma. Clinically, it’s useful for monitoring treatment response and checking for recurrence in patients with known pancreatic cancer, though it isn’t perfect for screening because levels can rise with biliary obstruction, liver disease, or other benign conditions. Other cancers have different hallmark markers—breast cancer is often associated with CA 15-3 or CEA, ovarian cancer with CA-125, and liver/hepatic cancers with AFP—making CA 19-9 the marker most strongly tied to pancreatic cancer.

CA 19-9 is a tumor marker most closely linked to pancreatic cancer. It is a carbohydrate antigen produced by pancreatic ductal cells, and levels tend to be elevated in pancreatic adenocarcinoma. Clinically, it’s useful for monitoring treatment response and checking for recurrence in patients with known pancreatic cancer, though it isn’t perfect for screening because levels can rise with biliary obstruction, liver disease, or other benign conditions. Other cancers have different hallmark markers—breast cancer is often associated with CA 15-3 or CEA, ovarian cancer with CA-125, and liver/hepatic cancers with AFP—making CA 19-9 the marker most strongly tied to pancreatic cancer.

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